Hippocampus and SH-SY5Y cells were lysed by tissue protein extraction reagent (T-PER) (Thermo Scientific, Waltham, MA, USA), or RIPA buffer (Biosesang, Gyeonggi-do, South Korea). Bitter Redberry, Box Tree, Boxwood, Budwood, Cornejo Florido, Cornel, Cornelian Tree, Cornouiller Américain, Cornouiller d'Amérique, Cornouiller à Fleurs, Cornouiller à Fleurs d'Amérique, Cornouiller de Floride, Cornus, Cornus florida, Dog-Tree, Dogwood, False Box, Flowering Dogwood, Green Ozier, Osier, Rose Willow, Sanguiñuelo Florido, Silky Cornel, Swamp Dogwood. Cornus officinalis (aka Shan Zhu Yu), a tree shrub grown in the tepid climates of China and Japan, serves as a vital anxiety reducer. ; Blakely, R.D. The effects of a Chinese herb, Cornus officinalis, on the motility of human sperm was studied. Activation of erk1/2, jnk and pkb by hydrogen peroxide in human sh-sy5y neuroblastoma cells: Role of erk1/2 in h2o2-induced cell death. Czerwinska, M.E. and fewer side effects [4,5]. Cornus officinalis (CO) and Achyranthes japonica (AJ) have traditionally been used as herbal medicines in East Asia for their anti-oxidative, anti-inflammatory, and anti-cancer effects [15,16,17]. Hepatoprotective and antioxidative activities of cornus officinalis against acetaminophen-induced hepatotoxicity in mice. Sozanski, T.; Kucharska, A.Z. Effect of different doses of corticosterone on depression-like behavior and hpa axis responses to a novel stressor. Brain network reorganization differs in response to stress in rats genetically predisposed to depression and stress-resilient rats. Call us at 1 315 4971058. The stressed hippocampus, synaptic plasticity and lost memories. De Kloet, E.R. ; Kim, K.Y. The best-known species of Comus is the Japanese cornelian cherry (Cornus officinalis Sieb. ; Huang, X.J. Did you or will you purchase this product in-store or online? Botanical & Other Names: Dogwood, Shan Zhu Yu, Cornus Officinalis, Dogwood Fruit Tonic Energy & Flavor: Meridian Affinity: Heart, Liver and Kidney Cornus can strengthen the kidneys and improve symptoms of impotence and premature ejaculation. ; Seo, Y.B. For men who suffer from Leaky penis with excessive precum, nervousness & anxiety, wet dreams, and seminal leakage. Help us to further improve by taking part in this short 5 minute survey, Chemopreventive Effect of β-Cryptoxanthin on Human Cervical Carcinoma (HeLa) Cells Is Modulated through Oxidative Stress-Induced Apoptosis, Neuroprotective Mechanisms of Three Natural Antioxidants on a Rat Model of Parkinson’s Disease: A Comparative Study, Endoplasmic Reticulum Stress-Induced Resistance to Doxorubicin Is Reversed by Mulberry Leaf Polyphenol Extract in Hepatocellular Carcinoma through Inhibition of COX-2, Oxidative Stress and Mitochondrial Dysfunctions in Neurological Diseases, Preventive Effects of Bioactive Natural Compouds, http://creativecommons.org/licenses/by/4.0/. Krishnan, V.; Nestler, E.J. Loganin is one of the major constituents derived from Corni fructus. Studer, L.; Spenger, C.; Seiler, R.W. View abstract. The statements, opinions and data contained in the journals are solely Please let us know what you think of our products and services. For men who suffer from Leaky penis with excessive precum, nervousness & anxiety, wet dreams, and seminal leakage. ; Han, B.H. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. ; Jin, G.Y. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Read more : Greater Burnet (Sanguisorba Officinalis) Overview, Health Benefits, Side effects. Wong, M.L. et Zucc., also known as fructus corni and jujube, is included in the Chinese Pharmacopoeia (2020), in sections related to the liver, kidney homeostasis, liver and kidney tonics, and astringent effects. Briefly, SH-SY5Y cells were seeded in 96-well black plates with clear bottoms at a density 1 × 10, SH-SY5Y cells were dispensed into a 96-well plate at a density of 1 × 10, Total RNA was extracted from cells according to the manufacturer’s instructions using a total RNA extraction kit (GeneAll, Seoul, South Korea). Uses, Benefits, Cures, Side Effects, Nutrients in Cornus Officinalis. (eCAM). The expressions of SOD and CAT were significantly (, In order to further explore the neuroprotective role of CC and FCC on H, In this study, we investigated the neuroprotective effects of CC and FCC using stress-induced hippocampal deficits in rats and H, Corticosterone is a marker of susceptibility to oxidative/nitrosative cerebral damage following exposure to stress in rats [, Serotonin is produced by nerve cells and transmits signals between nerve cells and plays a crucial role in the response to stress and antidepressant action [, BDNF plays a major role in neural development and plasticity in both health and disease [, The Bcl-2 family is well characterized as involved in the apoptotic process. The crude extract at a final concentration of 0.5 microgram/microliter in phosphate buffered saline (pH 7.4) increased sperm motility from 25.8 +/- 7.7% to 42.8 +/- 10.3% (i.e. ; Zhu, H.B. and Y.-J.C.; Data Curation, W.T. ; Joels, M.; Holsboer, F. Stress and the brain: From adaptation to disease. The Bax/Bcl-2 ratio was significantly increased in this study after being treated with H, The present data demonstrated that CC and especially FCC may mitigate the damage impact on the brain and inhibit H. Conceptualization, W.T., J.-H.L. Cornus officinalis (Shan Zhu Yu in TCM) Fructus Corni; Poria mushroom/fungus (Fu Ling in TCM) Turmeric (E Shu – also reviewed above) Phellodendron amurense (Huang Bo) Alisma plantago-aquatica (Ze Xie) Vaccaria segetalis (Liu Xing) Treatment periods in the studies ranged from one month to a year. Shan-Zhu-Yu, the dried and mature pulp of Cornus officinalis Sieb. It prefers acidic well-drained soil in full sun to … The cDNA was reverse-transcribed from 3 μg total RNA and the cDNA synthesis procedure was performed according to the manufacturer’s instructions (Thermo Fisher Scientific Korea Ltd. Seoul, South Korea). Only ten severe adverse events were reported, two with possible association with the therapy. Lee, N.H.; Seo, C.S. ; Dogan, B.; Akakin, D.; Yuksel, M.; Kasimay, O. FAQ. Med. This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Lee, B.; Sur, B.; Park, J.; Kim, S.H. Hippocampus and serum MDA were measured by thiobarbituric acid reactive substances (TBARS) kit (Cayman, Ann Arbor, MI, USA). Cancer . Effects of corni fructus on ovalbumin-induced airway inflammation and airway hyper-responsiveness in a mouse model of allergic asthma. Corni fructus (CF) is a fruit of Cornus officinalis Sieb. Gandhi, J.; Khera, L.; Gaur, N.; Paul, C.; Kaul, R. Role of modulator of inflammation cyclooxygenase-2 in gammaherpesvirus mediated tumorigenesis. Shi, C.; Zhang, Y.; Lu, Z.; Wang, Y. Solid-state fermentation of corn-soybean meal mixed feed with bacillus subtilis and enterococcus faecium for degrading antinutritional factors and enhancing nutritional value. It comes from ‘cornu,’ a Latin word meaning horn that is in resemblance to the density, strength, and looks of the wood. The fruit of Cornus officinalis is effective for treating liver and lung disease in traditional Chinese medicine . At this time there is not enough scientific information to determine an appropriate range of doses for American dogwood. Control of adult neurogenesis by programmed cell death in the mammalian brain. These new chemical structures were established through spectroscopic analysis (UV, IR, HRESIMS, 1D and 2D NMR). Cisplatin (Cis) has serious adverse side-effects that limit its clinical use. What is the side effects of Cornus Fructus Officinalis Extract Strychnine? Cornus is often combined with other all-natural herbs to ensure its effectiveness. ; Resources, S.-K.K. The species is hermaphrodite (has both male and female organs) and is pollinated by Insects. Ruffels, J.; Griffin, M.; Dickenson, J.M. Note: Gallic acid and rutin were used as standards. ; Suleman, M.A. ; Han, S.M. Lee, K.M. It has been used diffusely for curing dizziness, coldness, pain in the waist, frequent micturition, enuresis, impotence, and prospermia [ 17 ]. Effects of Cornus officinalis (CO) and Ribes fasciculatum (RF) extract on mRNA expression of adipogenesis-related genes and the lipid accumulation in 3T3-L1 cells. and J.-H.L. Oxidative stress plays a vital role in neurodegenerative diseases. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.© Therapeutic Research Faculty . Mitogen-activated protein kinases and reactive oxygen species: How can ros activate mapk pathways? This group evaluated the effects of C. officinalis seeds on diabetic complications by isolating compounds from the seeds and studying their effects on AGE formation, AR, and cataractogenesis. Cornus is an antidiuretic, so don’t combine with other diuretics. ; Kim, H.B. Biochem. After the reaction was finished, specificity was verified with the melting curve analysis. It is hardy to zone (UK) 6 and is not frost tender. Kim, G.H. There are many reports that either C. officinalis or iridoids isolated from it--loganin and morroniside--exert positive effects on lipid metabolism and possess antidiabetic effects (Park et al., 2009a,b; Yamabe et al., 2010; Park et al., 2010, 2011). Can J Physiol Pharmacol 2006;84:1267–1273. Hippocampal damage associated with prolonged and fatal stress in primates. We use cookies on our website to ensure you get the best experience. Swain, M.R. (check all that apply), What factors are most important to you? Cornus officinalis, after being stewed with yellow rice wine, has a stronger efficacy on nourishing kidneys, astringing semen, and reducing urination. MDA and NO levels were markedly (, Levels of serum corticosterone and β-endorphin were notably (, Previous study has shown that stress-induced oxidative stress may cause neurotoxicity by activating the mitogen-activated protein kinase (MAPK) family [, SH-SY5Y were treated with CC or FCC at concentrations of 20, 50, and 100 µg/mL, and the toxic dose on cell viability was 100 µg/mL compared with untreated cells (, The gene expressions of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and neuronal stress biomarkers brain-derived neurotrophic factor (BDNF) were examined by quantitative real-time RT-PCR. Cornin ameliorates cerebral infarction in rats by antioxidant action and stabilization of mitochondrial function. The fruit is used in healing. Thus, morroniside is a potential compound for clinical amelioration of the side effects of anticancer treatments. cDNA was subjected to quantitative real-time PCR (qPCR) on a CFX96 Real-Time PCR Detection System (Bio-Rad Laboratories, Hercules, CA) with SYBR Green I as double-stranded DNA-binding dye. The main symptoms of depression include permanent low spirit, mental retardation, physical discomfort, decreased volitional activity, and cognitive impairment, and the main clinical manifestations are low mood, lack of pleasure, decreased self-worth, and even suicidal thoughts [ 1 ; Jian, H.; Tian, J.W. Comp. Cornus officinalis commonly known as Japanese Cornel Cherry, Cornelian Cherry Dogwood, and European Cornel is a species of the flowering plant in the dogwood family Cornaceae. et Zucc., has been used as a tonic for the kidney in China for thousands of years. The present study was undertaken to elucidate the neuroprotective mechanism of CC and fermented CC (FCC) on stress and H2O2-induced oxidative stress damage in rats and SH-SY5Y cells. ; Cheng, H.M.; Sim, S.M. Mulberry leaves protect rat tissues from immobilization stress-induced inflammation. College of Veterinary Medicine and Bio-safety Research Institute, Jeonbuk National University, Iksan 54596, Korea, Sunchang Research Institute of Health and Longevity, 427-128 Indok-ro, Ingye-myeon, Sunchang-gun, Jeollabuk-do 56015, Korea, Department of Pharmacology and Toxicology, Sylhet Agricultural University, Sylhet 3100, Bangladesh, Imsil Cheese Livestock Cooperative Association, 275 Galma-ri, Imsil-eup, Imsil-gun, Jeollabuk-do 55924, Korea, Imsil Cheese & Food Research Institute, 50 Doin 2-gil, Seongsu-myeon, Imsil-gun, Jeollabuk-do 55918, Korea. 19,23,30–32 Gass, N.; Becker, R.; Schwarz, A.J. ; Hao, J.; Jiang, J. Cyclooxygenase-2 contributes to oxidopamine-mediated neuronal inflammation and injury via the prostaglandin e2 receptor ep2 subtype. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Side Effects & Safety When taken by mouth: There isn't enough reliable information to know if American dogwood is safe or what the side effects might be. Methods: The hyaluronidase inhibitory activity of an active extract of this formulation (AEF) was evaluated in vitro. Son, Y.; Cheong, Y.K. This deciduous large shrub or small tree has picturesque multi-stemmed, low branches with an open oval to round habit. Information from this source is evidence-based and objective, and without commercial influence. ; Lee, S.C.; Lee, J.H. Have you ever purchased AMERICAN DOGWOOD? Neuroprotective effects of flavones on hydrogen peroxide-induced apoptosis in sh-sy5y neuroblostoma cells. It is in flower from February to March, and the seeds ripen in September. There are some other similar testosterone boosters available from Nutragreen biotechnology such as ; Lee, A.S.; Choi, I. Melandrii herba extract attenuates h(2)o(2)-induced neurotoxicity in human neuroblastoma sh-sy5y cells and scopolamine-induced memory impairment in mice. Here we investigated whether morroniside was an orthosteric GLP‐1 receptor agonist and had anti‐hypersensitivity activities in a model of neuropathic pain. Effects of salvia sclarea on chronic immobilization stress induced endothelial dysfunction in rats. Our dedicated information section provides allows you to learn more about MDPI. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using. This research was supported by research funds of Jeonbuk National University in 2018, and the Ministry of Trade, Industry, and Energy (MOTIE), South Korea, under the “Regional Specialized Industry Development Program” (reference number R0004385) supervised by the Korea Institute for Advancement of Technology (KIAT). Manach, C.; Scalbert, A.; Morand, C.; Remesy, C.; Jimenez, L. Polyphenols: Food sources and bioavailability. Dogwood (Cornus Florida) Health Benefits. List of various diseases cured by Cornus Officinalis. ; et al. ; Writing—Review & Editing, J.Z., M.R.A. ; Pae, H.O. Media in category "Cornus officinalis" The following 54 files are in this category, out of 54 total. Hippocampal vulnerability to stress and aging: Possible role of neurotrophic factors. Severe adverse events were reported, two with possible association with the glucocorticoid antagonist... Scientific information to determine an appropriate range of pharmacological activities ( e.g. antioxidant... 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